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SFRH/BD/112526/2015, UIDB/00709/2020, UIDP/04378/2020, UIDP/00709/2020, UIDB/04378/2020)

doi: 10.1016/j.ejmech.2022.114884 6 TapWDGelderblomHPalmeriniEDesaiJBauerSBlayJYet al

Among antituberculous medications, INH, RIF, EMB, clofazimine, bedaquiline, and delamanid are known to be CYP450 enzyme system substrates or can impact its metabolic activity by induction or inhibition

Research has explored this combination for its potential effects on several biological systems in preclinical models: Growth hormone secretion patterns and pituitary function Protein synthesis and metabolic processes Cellular recovery and regeneration mechanisms Neuroendocrine signaling pathways Nutrient utilization in model organisms Because these findings are preliminary and limited to laboratory environments, all potential biological effects remain theoretical and unproven